Gilbert's syndrome: nutrition and lifestyle
Gilbert's syndrome is a genetic condition characterized by intermittent episodes of elevated bilirubin levels in the blood. The most common symptoms include:
Yellowness of the whites of the eyes (as a result of slightly higher levels of bilirubin in the blood);
Periodic pain in the right upper abdomen;
Yellowness of the feet and hands;
Fatigue, lethargy, and lack of energy;
Poor tolerance to fats and alcohol;
Dark urine and dark stools.
Gilbert's syndrome is a genetic disorder characterized by a defect in the UGT1A1 gene, which is responsible for the second phase of detoxification. This defect leads to periodic increases in unbound bilirubin.
The UGT1A1 gene is involved in the breakdown of bilirubin and estrogen. As a result women often have hormonal imbalances.
With this Gilbert's syndrome, bilirubin is not properly detoxified. Therefore, we see high levels of bilirubin, especially during stress, during exercise, during fasting.
The UGT1A1 gene is responsible for the excretion of bilirubin, which is released into bile and urine. This explains why the color of urine and stool can change with Gilbert's syndrome.
Yellowing of the sclera of the eyes, feet and palms may also occur. The disease is common but often undiagnosed. This condition is considered relatively safe, but there are varying degrees of severity. More common in the white race.
These recommendations should be followed by people with confirmed Gilbert's Syndrome (genetic changes in UGT1A1):
1. Meals 3-4 times a day. It is worth avoiding starvation and monitor the amount of protein in the diet, and eat fats in small amounts, dividing them in equal portions throughout the day;
2. Monitor the amount of water. Your minimum is 30 ml per 1 kg of weight;
3. Sleep. Maintain sleep patterns and monitor sleep quality;
4. Avoid nutrient deficiencies: magnesium, B vitamins, iron. Also check your thyroid function regularly;
5. Omega-3 supplements are not recommended;
6. Discuss about Calcium D Glucarate supplementation with your Healthcare Professional;
7. It is recommended that women regularly do breast ultrasound, due to detoxification disorders and the possible predominance of estrogens.
Gilbert's syndrome is a genetic condition that can be managed. If you have any questions regarding its diagnosis, recommended monitoring for individuals with this gene disorder, or if you seek advice on lifestyle and nutrition recommendations, feel free to reach out to me for guidance.
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